Yeah, it depends on the hardware and how it interacts with your device.
I buy a fair bit of hardware from Adafruit. They are mostly Microcontroller orientated. Arduino and the stuff they make themselves in house. A lot of their breakouts have a nice right up for Arduino, and note at the end saying will also work with a Raspberry Pi. More often than not though, they leave figuring out how to make it work with a Pi to you.
Here its kind of the other way around. Pi first, with a good write up how to do it. Then an also works with Arduino note, but it’s up to you to figure out how to do it with Arduino.
These aren’t complaints just observations.
It is what it is though, the Pi is Arm and likely will be for a long long time. If you want to use the GPIO you have to keep in mind the logic level and instruction set etc. Anything that works via python should be doable, if you can find a library etc.
I had one of those displays, 7 inch I believe. Its resistive touch by the way, not sure if it matters. I liked it better than the capacitive. Just about any stylus will work. Screen surface is soft though and easier to damage. The only thing I didn’t like was the two cords sticking out the side. I eventually replaced it with the Pi foundation 7 touch screen.