I have a Matrix Portal, and swapped it for the Interstate 75 W.
For me, it was easier to use Micro Python and Pimoroni’s Pico Graphics. It was what I was already used to. I struggled with Circuit Python and Adafruit’s graphics offering. I went Matrix Portal because it had WIFI. At the time of purchase there was no Interstate 75 “W”
Thats just me though, it all depends on what your used to using software / programing wise. And what your displaying on the Matrix. I’m just displaying weather info in a text format.
Interstate 75 with multiple HUB-75 LED matrix panels - Support - Pimoroni Buccaneers