No sound and no controls in game - menu ok

Just built my Picade with a 12” screen. Set up my controls as suggested. Boots up fine, splash screen video has sound, controls work fine in Retropie menus and preview videos of games have sound. However when I start a game, doesn’t matter which emulator, I have no sound and no controls. Luckily the hard coded escape key works. Connected and configured a PS4 controller via USB. Works fine.
I am a Raspberry, Linux, Retropie, RetroArch noob, so any help or input where to start debugging and how to debug would be great.

Got the sound working now in-game.
Still no or almost no controls in-game. Updated picade.hex to the current (?) Version but to no effect. Rii Keyboard or PS4 controller work.